Heart and Vascular Responses Across the Lifespan in Ts65Dn Mice, a Model of Down Syndrome

Lara DeRuisseau (EX SCI) PI, Kevin Heffernan (EX SCI) co-I, and Melissa Bates (University of Iowa) co-I, NIH, 9/1/20-8/31/22.

Down syndrome (Ds) is a developmental disability that results from triplication of chromosome 21. Persons with Ds are confronted with a variety of daily challenges including heart defects at birth and lower blood pressure and heart rate at rest and during times of activity. This work aims to uncover contributors of the cardiovascular phenotype observed in Ds by using the Ts65Dn mouse, a model of Ds. The team includes Lara DeRuisseau, research professor in Exercise Science at Falk College as PI, and Kevin Heffernan, associate professor in the Department of Exercise Science at Falk College and Melissa Bates, assistant professor in the Department of Health and Human Physiology at the University of Iowa as co-Is.