Falk College strives to achieve excellence in education not only through good teaching but also through participation in active research. Our students benefit by learning from researchers who are working at the cutting-edge of knowledge, within well-equipped laboratories, and in projects that are both domestic and abroad. We encourage both undergraduates and graduate engagement to achieve not only a rewarding educational experience but also enhanced career opportunities upon graduation. Learn more about the different types of research awards.
2021-2022 SU CUSE GrantThe Association of the EGLN1 Gene with the High Aerobic Capacity (VO2max) of Nepali Sherpa at High-altitude
There is compelling evidence that highland-native populations in the Himalayas (Sherpa,Tibetans) and the South American Andes (Quechua) are genetically adapted to chronic hypobaric hypoxia. For example, both population groups are tolerant to extreme high-altitude and show impressive physical work capacity in hypoxia. In Peruvian Quechua, we have identified several high frequency genetic markers that are associated with a significantly higher aerobic capacity (VO2max) at high-altitude. These markers were found in a gene known as EGLN1 which is a central component of the Hypoxia Inducible Factor (HIF) pathway. The HIF-pathway regulates the cellular response to hypoxia. In this CUSE grant, we will seek to replicate our Peruvian findings by collecting DNA and measuring VO2max in n=70 Sherpa highlanders at 4,240 m altitude in Nepal.
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